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CORE TECHNOLOGY

Multimer Detection System

Multimer Detection System (MDS) is sandwich assay using capturing antibodies and epitope-overlapping detection
antibodies for the detection of only oligomers or multimers from monomers in protein-misfolding diseases.

Applicable Diseases

Hundreds of different disorders caused by neurodegeneration, the term referring to several conditions that result in the progressive
loss of structure or function of neurons, come under the neurodegenerative disease. A key molecular pathway implicated in diverse neurodegenerative diseases is the misfolding, aggregation, and accumulation of proteins in the brain.

Compelling evidence strongly supports that accumulation of misfolded proteins leads to synaptic dysfunction,
neuronal apoptosis, brain damage, and disease. PeopleBio’s core technology, Multimer Detection System (MDS)
detecting only aggregated forms of disease-associated proteins is applicable to
the neurodegenerative diseases’ biomarker discovery, early diagnostics, and high-throughput screening.

Alzheimer’s disease

As a typical neurodegenerative disease, it is the most common form of dementia incurring confusion, disturbance in short-term memory, loss of cognitive function, and mental disorders such as depressions, progressing gradually to death. Two abnormal structures called beta-amyloid plaques and tau tangles are prime suspects in damaging and killing nerve cells. Oligomeric Aβ is instrumental to the progression of forming the plaques.

TARGET Protein: Amyloid-β oligomers (multimers)

Parkinson’s disease

A neurodegenerative disorder in the central nervous system, often called movement disorders, impairs the motor skills, speech, and other functions caused by deficiency of dopamine produced from substantia nigra. Alpha-synucleins aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, in Parkinson's disease.

TARGET Protein: α Synuclein oligomers (multimer)

Creutzfeldt-Jakob’s disease

Transmissible Spongiform Encephalopathy (TSE) or Prion diseases are zoonoses incurred by abnormal prion. Although the fatality of the disease is 100%, no therapeutics and preventions are available at present time. The cause of Creutzfeldt-Jakob disease and other TSEs appears to be abnormal versions of a kind of protein called a prion. Normally these proteins are harmless. But when they're misshapen, they become infectious and can harm normal biological processes.

TARGET Protein: Prion oligomers (multimers)